The Imhof group studies the proteomic composition of distinct chromatin domains, the mechanisms that operate to maintain the composition of histone modifications and the associated proteins at a given DNA locus. We are interested in the effect of the concentration of key metabolites on the activity of enzymes that establish a specific chromatin structure and investigate how the modification patterns of changes upon physiological challenges such as memory formation or ageing. Our main model system is the fruit fly Drosophila melanogaster. It is also an excellent system to investigate the role of genomic conflict in the formation of species, which is mediated by incompatible chromatin and is another big interest of the lab.
Zentrallabor für Proteinanalytik (Protein Analysis Unit)
Großhadernerstr. 9 / Raum NC01.043
The Rippe lab has a long-standing interest to reveal structure-function relationships of chromatin subcompartments and underlying assembly mechanisms. Within this are of our research we are studying dense heterochromatin foci (chromocenters) involved in silencing of repeat transcription, the nucleolus and RNA polymerase II subcompartments as site of active transcription and complexes of PML nuclear bodies at telomeres. The functional properties of these macromolecular assemblies are dissected by fluorescence microscopy based methods in conjunction with deep sequencing techniques at the single cell level.
Deutsches Krebsforschungszentrum & BioQuant
Division of Chromatin Networks
Phone: +49 6221 54 51376 (office, BioQuant room 645) / +49-6221-54-51372 (lab, BioQuant room 622)