Publications

2021

Natalia Y. Kochanova, Tamas Schauer, Grusha Primal Mathias, Andrea Lukacs, Andreas Schmidt, Andrew Flatley, Aloys Schepers, Andreas W. Thomae, Axel Imhof (2021) A multi-layered structure of the interphase chromocenter revealed by proximity-based biotinylation, Nucleic Acids Research 48(8), p. 4161-4178, Oxford Academic, url, doi:10.1093/NAR/GKAA145

Lukas Frank, Robin Weinmann, Fabian Erdel, Jorge Trojanowski, Karsten Rippe (2021) Transcriptional Activation of Heterochromatin by Recruitment of dCas9 Activators, Enhancer and Promotors. Methods in Molecular Biology 2351, T. Borggrefe, B.D. Giaimo (ed.), p. 307-320, Humana, New York, NY, url, doi:10.1007/978-1-0716-1597-3_17

Andrea Lukacs, Andreas W. Thomae, Peter Krueger, Tamas Schauer, Anuroop V. Venkatasubramani, Natalia Y. Kochanova, Wasim Aftab, Rupam Choudhury, Ignasi Forne, Axel Imhof (2021) The integrity of the HMR complex is necessary for centromeric binding and reproductive isolation in Drosophila, PLoS Genetics 17(8), p. e1009744, Public Library of Science, url, doi:10.1371/journal.pgen.1009744

Jorge Trojanowski, Lukas Frank, Anne Rademacher, Pranas Grigaitis, Karsten Rippe (2021) Transcription activation is enhanced by multivalent interactions independent of liquid-liquid phase separation, bioRxiv, p. 2021.01.27.428421, Cold Spring Harbor Laboratory, url, doi:10.1101/2021.01.27.428421

Peter E.A. Ash, Shuwen Lei, Jenifer Shattuck, Samantha Boudeau, Yari Carlomagno, Maria Medalla, Bryce L. Mashimo, Guillermo Socorro, Louloua F.A. Al-Mohanna, Lulu Jiang, Muhammet M. Öztürk, Mark Knobel, Pavel Ivanov, Leonard Petrucelli, Susanne Wegmann, Nicholas M. Kanaan, Benjamin Wolozin (2021) TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau, Proceedings of the National Academy of Sciences of the United States of America 118(9), National Academy of Sciences, url, doi:10.1073/pnas.2014188118

Amra Noa, Hui Shun Kuan, Vera Aschmann, Vasily Zaburdaev, Lennart Hilbert (2021) The hierarchical packing of euchromatin domains can be described as multiplicative cascades, PLoS Computational Biology 17(5), p. e1008974, Public Library of Science, url, doi:10.1371/journal.pcbi.1008974

Agnieszka Pancholi, Tim Klingberg, Weichun Zhang, Roshan Prizak, Irina Mamontova, Amra Noa, A.Y. Kobitski, G.U. Nienhaus, Vasily Zaburdaev, Lennart Hilbert (2021) RNA polymerase II clusters form in line with liquid phase wetting of chromatin, bioRxiv, p. 2021.02.03.429626, Cold Spring Harbor Laboratory, url, doi:10.1101/2021.02.03.429626

Bart W. Hoogenboom, Loren E. Hough, Edward A. Lemke, Roderick Y.H. Lim, Patrick R. Onck, Anton Zilman (2021) Physics of the nuclear pore complex: Theory, modeling and experiment, Physics Reports 921, p. 1-53, North-Holland, doi:10.1016/j.physrep.2021.03.003

Amra Noa, Hui Shun Kuan, Vera Aschmann, Vasily Zaburdaev, Lennart Hilbert (2021) The hierarchical packing of euchromatin domains can be described as multiplicative cascades, PLoS Computational Biology 17(5), p. e1008974, Public Library of Science, url, doi:10.1371/journal.pcbi.1008974

Imke Baade, Saskia Hutten, Erin L. Sternburg, Marius Pörschke, Mario Hofweber, Dorothee Dormann, Ralph H. Kehlenbach (2021) The RNA-binding protein FUS is chaperoned and imported into the nucleus by a network of import receptors, Journal of Biological Chemistry 296, J Biol Chem, url, doi:10.1016/j.jbc.2021.100659

Lara Aletta Gruijs da Silva, Francesca Simonetti, Saskia Hutten, Henrick Riemenschneider, Erin L Sternburg, Lisa M Pietrek, Jakob Gebel, Volker Doetsch, Dieter Edbauer, Gerhard Hummer, Lukas S Stelzl, Dorothee Dormann (2021) Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation, bioRxiv, p. 2021.04.30.442163, Cold Spring Harbor Laboratory, url, doi:10.1101/2021.04.30.442163

Jasper J. Michels, Mateusz Brzezinski, Tom Scheidt, Edward A. Lemke, Sapun Parekh (2021) Role of Solvent Compatibility in the Phase Behavior of Binary Solutions of Weakly Associating Multivalent Polymers, bioRxiv, p. 2021.09.09.459431, Cold Spring Harbor Laboratory, url, doi:10.1101/2021.09.09.459431

2020

Johannes Söding, David Zwicker, Salma Sohrabi-Jahromi, Marc Boehning, Jan Kirschbaum (2020) Mechanisms for Active Regulation of Biomolecular Condensates, Trends in Cell Biology 30(1), p. 4-14, Elsevier, url, doi:10.1016/j.tcb.2019.10.006

Tina Ukmar-Godec, Susanne Wegmann, Markus Zweckstetter (2020) Biomolecular condensation of the microtubule-associated protein tau, Seminars in Cell & Developmental Biology 99, p. 202-214, Academic Press, doi:10.1016/J.SEMCDB.2019.06.007

Giorgia Celetti, Giulia Paci, Joana Caria, Virginia VanDelinder, George Bachand, Edward A. Lemke (2020) The liquid state of FG-nucleoporins mimics permeability barrier properties of nuclear pore complexes, Journal of Cell Biology 219(1), Rockefeller University Press, url, doi:10.1083/jcb.201907157

Jaroslaw Majewski, Emmalee M. Jones, Crystal M. Vander Zanden, Jacek Biernat, Eckhard Mandelkow, Eva Y. Chi (2020) Lipid membrane templated misfolding and self-assembly of intrinsically disordered tau protein, Scientific Reports 10(1), p. 1-13, Nature Publishing Group, url, doi:10.1038/s41598-020-70208-6

Ariel Erijman, Lukasz Kozlowski, Salma Sohrabi-Jahromi, James Fishburn, Linda Warfield, Jacob Schreiber, William S. Noble, Johannes Söding, Steven Hahn (2020) A High-Throughput Screen for Transcription Activation Domains Reveals Their Sequence Features and Permits Prediction by Deep Learning, Molecular Cell 78(5), p. 890-902.e6, Cell Press, doi:10.1016/j.molcel.2020.04.020

Nike Heinß, Mikhail Sushkin, Miao Yu, Edward A. Lemke (2020) Multifunctionality of F-rich nucleoporins, Biochemical Society Transactions 48(6), p. 2603-2614, Portland Press, url, doi:10.1042/BST20200357

Saskia Hutten, Sinem Usluer, Benjamin Bourgeois, Francesca Simonetti, Hana M. Odeh, Charlotte M. Fare, Mareike Czuppa, Marian Hruska-Plochan, Mario Hofweber, Magdalini Polymenidou, James Shorter, Dieter Edbauer, Tobias Madl, Dorothee Dormann (2020) Nuclear Import Receptors Directly Bind to Arginine-Rich Dipeptide Repeat Proteins and Suppress Their Pathological Interactions, Cell Reports 33(12), Cell Rep, url, doi:10.1016/j.celrep.2020.108538

Fabian Erdel, Anne Rademacher, Rifka Vlijm, Jana Tünnermann, Lukas Frank, Robin Weinmann, Elisabeth Schweigert, Klaus Yserentant, Johan Hummert, Caroline Bauer, Sabrina Schumacher, Ahmad Al Alwash, Christophe Normand, Dirk Peter Herten, Johann Engelhardt, Karsten Rippe (2020) Mouse Heterochromatin Adopts Digital Compaction States without Showing Hallmarks of HP1-Driven Liquid-Liquid Phase Separation, Molecular Cell 78(2), p. 236-249.e7, Cell Press, doi:10.1016/j.molcel.2020.02.005

Lukas Frank, Karsten Rippe (2020) Repetitive RNAs as Regulators of Chromatin-Associated Subcompartment Formation by Phase Separation, Journal of Molecular Biology 432(15), p. 4270-4286, Academic Press, doi:10.1016/j.jmb.2020.04.015

Carsten Donau, Fabian Späth, Marilyne Sosson, Brigitte A.K. Kriebisch, Fabian Schnitter, Marta Tena-Solsona, Hyun Seo Kang, Elia Salibi, Michael Sattler, Hannes Mutschler, Job Boekhoven (2020) Active coacervate droplets as a model for membraneless organelles and protocells, Nature Communications 11(1), p. 1-10, Nature Publishing Group, url, doi:10.1038/s41467-020-18815-9

A. Klosin, F. Oltsch, T. Harmon, A. Honigmann, F. Jülicher, A. A. Hyman, C. Zechner (2020) Phase separation provides a mechanism to reduce noise in cells, Science 367(6476), p. 464-468, American Association for the Advancement of Science, url, doi:10.1126/science.aav6691

Saskia Hutten, Sinem Usluer, Benjamin Bourgeois, Francesca Simonetti, Hana M. Odeh, Charlotte M. Fare, Mareike Czuppa, Marian Hruska-Plochan, Mario Hofweber, Magdalini Polymenidou, James Shorter, Dieter Edbauer, Tobias Madl, Dorothee Dormann (2020) Nuclear Import Receptors Directly Bind to Arginine-Rich Dipeptide Repeat Proteins and Suppress Their Pathological Interactions, Cell Reports 33(12), Cell Rep, url, doi:10.1016/j.celrep.2020.108538

Saskia Hutten, Dorothee Dormann (2020) A Quantitative Assay to Measure Stress Granule Association of Proteins and Peptides in Semi-permeabilized Human Cells, BIO-PROTOCOL 10(24), p. e3846, Bio Protoc, url, doi:10.21769/bioprotoc.3846

2019

Sara S. Ribeiro, Nirnay Samanta, Simon Ebbinghaus, João C. Marcos (2019) The synergic effect of water and biomolecules in intracellular phase separation, Nature Reviews Chemistry 2019 3:9 3(9), p. 552-561, Nature Publishing Group, url, doi:10.1038/s41570-019-0120-4

Mario Hofweber, Dorothee Dormann (2019) Friend or foe-Post-translational modifications as regulators of phase separation and RNP granule dynamics, Journal of Biological Chemistry 294(18), p. 7137-7150, J Biol Chem, url, doi:10.1074/jbc.TM118.001189

2018

Sara Ribeiro, Simon Ebbinghaus, João C. Marcos (2018) Protein folding and quinary interactions: creating cellular organisation through functional disorder, FEBS Letters 592(18), p. 3040-3053, John Wiley & Sons, Ltd, url, doi:10.1002/1873-3468.13211

Lennart Hilbert, Yuko Sato, Hiroshi Kimura, Frank Jülicher, Alf Honigmann, Vasily Zaburdaev, Nadine L. Vastenhouw (2018) Transcription organizes euchromatin similar to an active microemulsion, bioRxiv, p. 234112, Cold Spring Harbor Laboratory, url, doi:10.1101/234112

2017

Jan Niklas Tants, Stephanie Fesser, Thomas Kern, Ralf Stehle, Arie Geerlof, Christoph Wunderlich, Michael Juen, Christoph Hartlmüller, Romy Böttcher, Stefan Kunzelmann, Oliver Lange, Christoph Kreutz, Klaus Förstemann, Michael Sattler (2017) Molecular basis for asymmetry sensing of siRNAs by the Drosophila Loqs-PD/Dcr-2 complex in RNA interference, Nucleic Acids Research 45(21), p. 12536-12550, Oxford Academic, url, doi:10.1093/NAR/GKX886