Molecular mechanisms of functional phase separation in eukaryotic gene transcription


This is an integrative project involving complementary expertise in gene activation (Cramer lab), bioinformatics (Soeding lab) and NMR spectroscopy (Zweckstetter lab).

Patrick  Cramer

Johannes Soeding

Markus Zweckstetter


Erijman A, Kozlowski L, Sohrabi-Jahromi S, et al. A High-Throughput Screen for Transcription Activation Domains Reveals Their Sequence Features and Permits Prediction by Deep Learning [published online ahead of print, 2020 May 12]. Mol Cell. 2020;S1097-2765(20)30262-8. doi:10.1016/j.molcel.2020.04.020 MolCell-2020-Erijman-Soding-Hahn-HT-screen-for-Transcription-activation-domains-reveals-seq-characteristics
Sohrabi-Jahromi S, Hofmann KB, Boltendahl A, et al. Transcriptome maps of general eukaryotic RNA degradation factors. Elife. 2019;8:e47040. Published 2019 May 28. doi:10.7554/eLife.47040Elife-2019-SohrabiJahromi-Cramer-Transcriptome-maps-of-general-euk-RNA degradation-factors

Söding, J.; Zwicker, D.; Sohrabi-Jahromi, S.; Boehning, M.; Kirschbaum, J.: Mechanisms of active regulation of biomolecular condensates. Trends Cell Biol. (2019) DOI: TiCB-2019-Soding-et-al-Mechanisms-of-active-reg-of-biomol-condensates-Incl-SI

Ukmar-Godec, T.; Hutten, S.; Grieshop, M. P.; Rezaei-Ghaleh, N.; Cima-Omori, M. O.; Biernat, J.; Mandelkow, E.; Söding, J.; Dormann, D.; Zweckstetter, M.: Lysine/RNA-interactions drive and regulate biomolecular condensation. Nat. Commun. (2019) 10 (1). DOI: NatCommun-2019-UkmarGodec-Zweckstetter-Lysine-RNA-interactions-drive-and-reg-biomolecular-interactions